Hi, no it won't... I've been using the regula antispam plugin for many years and since the x64 version of the Bat! it doesn't work anymore. As you can see, this information is given by Ritlabs :
*The 64-bit version of The Bat! does not accept 32-bit plugins. If your plugin stopped working after installing The Bat! 64-bit, you should either get the 64-bit version of the plugin or switch back to the 32-bit version of The Bat!
I've seen this information, but as I can imagine most of plugins "available" at ritlabs site are for 32bit version. So currently, I can assume, that 64bit version should be running w/o plugins, cause there're no new x64 versions of them. That's a pity
The development of the Regula plug-in is stopped since a few years. The stand alone application "Phalanx" has more features and is fully compatible with The Bat! 32 and 64 bit (http://www.gaijin.at/en/dlphalanx.php).